Soyuz-U: Progress MS-04 (65P)

Failure:The launch proceeded normally until telemetry was lost at T+382 seconds, about two minutes into the Blok I stage burn. At this time, the Progress apparently separated from the third stage, almost six minutes earlier than nominal. A high altitude explosion was reported over the skies of Tuva, and debris from the third stage and Progress impacted in a mountainous area approximately 2200 miles (3500 km) downrange from Baikonur.